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Mifeprex blocks the actions of a hormone needed to maintain a pregnancy.

It is used to end an early pregnancy that is not further along than 70 days (10 weeks) after the first day of your last menstrual period. It is used together with another medicine called misoprostol (Cytotec).

It is available only from a certified healthcare provider under a special program. You must be registered in the program and understand the risks of taking Mifeprex.


This medication guide provides information about the tablet brand of mifepristone. Korlym is another brand of mifepristone that is not covered in this medication guide.

It may also be used for purposes not listed in this medication guide.

What are the possible side effects of ?

It may cause serious side effects including:

  • a fever higher than 100.4 degrees (38 degrees C), lasting longer than 4 hours,
  • general ill feeling,
  • fast heartbeats,
  • severe pelvic pain or tenderness,
  • severe or ongoing nausea,
  • vomiting,
  • diarrhea,
  • weakness, and
  • no vaginal bleeding at all after taking Mifeprex RU486

How to Take Mifeprex

To receive Mifeprex, you’ll need to see your healthcare provider. The following are additional details on what to expect.1

Day one

  • Take one tablet of 200 milligrams (mg) by mouth.
  • If your healthcare provider didn’t give you four tablets of misoprostol 200 micrograms (mcg), they will give you a prescription to fill this medication at the pharmacy. You will take misoprostol 24 to 48 hours after your initial Mifeprex dose.

Between 24 to 48 hours after your initial Mifeprex dose

  • Place two misoprostol 200-microgram tablets on the inside of your left cheek.
  • Place another two misoprostol 200-microgram tablets on the inside of your right cheek.
  • Let the tablets dissolve on the side of your cheeks for 30 minutes.
  • Then, drink some water or another beverage to swallow any remaining pieces of medication in your mouth.

Seven to 14 days after taking your initial Mifeprex dose

  • Follow up with your healthcare provider to assess your health status.
  • Your healthcare provider will also determine whether you bled and your pregnancy passed through your uterus.
  • If your pregnancy hasn’t ended or passed through your uterus, your healthcare provider will advise you on next steps.

1 Kit, 2 Kit's, 3 Kit's

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